- Molecular NameDinoprost
- SynonymNA
- Weight354.487
- Drugbank_IDDB01160
- ACS_NO551-11-1
- Show 3D model
- LogP (experiment)2.72
- LogP (predicted, AB/LogP v2.0)2.61
- pkaN/A
- LogD (pH=7, predicted)0.51
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-0.85
- LogSw (predicted, AB/LogsW2.0)1.74
- Sw (mg/ml) (predicted, ACD/Labs)0.33
- No.of HBond Donors4
- No.of HBond Acceptors5
- No.of Rotatable Bonds12
- TPSA97.99
- StatusFDA approved
- AdministrationIntravenous (to induce labor), intra-amniotic (to induce abortion)
- PharmacologyUsed in medicine to induce labor and as an abortifacient.
- Absorption_valueN/A
- Absorption (description)Slowly absorbed from the amniotic fluid into systemic circulation.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmEnzymatic dehydrogenation primarily in the maternal lungs and also in the liver.
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityAlthough overdose by intra-amniotic administration of dinoprost has not been reported, exaggeration of the nausea, vomiting, and diarrhea that occur with normal doses would be expected.
- LD50 (rat)N/A
- LD50 (mouse)N/A