- Molecular NameAlprostadil
- Synonymalprostadil
- Weight354.487
- Drugbank_IDDB00770
- ACS_NO745-65-3
- Show 3D model
- LogP (experiment)3.2
- LogP (predicted, AB/LogP v2.0)3.2
- pka4.85
- LogD (pH=7, predicted)1.1
- Solubility (experiment)0.0267 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.92
- LogSw (predicted, AB/LogsW2.0)0.59
- Sw (mg/ml) (predicted, ACD/Labs)0.3
- No.of HBond Donors3
- No.of HBond Acceptors5
- No.of Rotatable Bonds13
- TPSA94.83
- StatusFDA approved
- AdministrationIntravenous
- PharmacologyA drug in the treatment of erectile dysfunction and has vasodilatory properties.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability15.0
- Protein binding81.0
- Volume of distribution (VD)0.8 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmBetween 60 and 90% (depending on dose) is rapidly metabolised by oxidation during passage through pulmonary circulation. It is also metabolised by the liver and kidneys to prostaglandin E0 (PGE0) and 15-hydroxy-PGE0.
- Half lifeN/A
- ExcretionThe drug is excreted principally in urine (88% of a dose) as metabolites and a small amount is excreted in faeces via bile (12%).
- Urinary ExcretionN/A
- ClerancePlasma, 115 L/min; also reported as 20 mL/min/kg.
- ToxicityOral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
- LD50 (rat)N/A
- LD50 (mouse)N/A