• Molecular NameAceclofenac
  • SynonymNA
  • Weight354.189
  • Drugbank_IDN/A
  • ACS_NO89796-99-6
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  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)4.07
  • pkaN/A
  • LogD (pH=7, predicted)1.77
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.08
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.08
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds7
  • TPSA75.63
  • StatusPOM(UK)
  • Administrationoral, topical
  • PharmacologyA non-steroidal anti-inflammatory drug.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding99.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt is metabolised in hepatocytes and microsomes to 4′-hydroxyaceclofenac, which can undergo further conjugation. Other metabolites also identified include diclofenac and 4-hydroxydiclofenac, and their hydroxylated derivatives.
  • Half life4h
  • Excretion70% of an administered dose is excreted in urine as glucuronides of aceclofenac and diclofenac.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityType III hypersensitivity reactions have been reported.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A