• Molecular NameMethadyl Acetate
  • SynonymAcetilmetadol [inn-spanish]; Acetylmethadol; Acetylmethadolum [inn-latin]; Betamethadol
  • Weight353.506
  • Drugbank_IDDB01433
  • ACS_NO1477-40-3
  • Show 3D model
  • LogP (experiment)4.27
  • LogP (predicted, AB/LogP v2.0)4.93
  • pkaN/A
  • LogD (pH=7, predicted)2.98
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.23
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds9
  • TPSA29.54
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA synthetic opioid similar in structure to methadone. It has a long duration of action due to its active metabolites. It was approved in 1993 by the U.S. Food and Drug Administration for use in the treatment of opioid dependence.
  • Absorption_valueN/A
  • Absorption (description)LAAM is rapidly absorbed from an oral solution.
  • Caco_2N/A
  • Bioavailability47.0
  • Protein binding80.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmCYP3A4
  • Half life2.6 days
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySigns of overdose include apnea, circulatory collapse, pulmonary edema, cardiac arrest, and death.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A