- Molecular NameAnileridine
- SynonymAnileridina [INN-Spanish]; Anileridinum [INN-Latin]; Phthalylsulfathiazole; Sulfathalidine
- Weight352.478
- Drugbank_IDDB00913
- ACS_NO144-14-9
- Show 2D model
- LogP (experiment)4.1
- LogP (predicted, AB/LogP v2.0)3.43
- pka3.7, 7.5
- LogD (pH=7, predicted)2.61
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.09
- LogSw (predicted, AB/LogsW2.0)0.27
- Sw (mg/ml) (predicted, ACD/Labs)0.14
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds7
- TPSA55.56
- StatusFDA approved
- AdministrationTablets, injection
- PharmacologyA synthetic opioid and strong analgesic medication.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding95.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised by hydrolysis to anileridinic acid followed by acetylation to acetylanileridinic acid; conjugation with acetic acid followed by partial de-esterification to acetylanileridinic acid also occurs.
- Half lifeN/A
- ExcretionAfter oral administration, 5% of the dose is excreted in the urine as unchanged drug, with 7 to 14% as free anileridinic acid, 1 to 2% as acetylanileridinic acid, 0.5 to 2% as acetylanileridine, and 15 to 35% as diazotisable metabolites, tentatively identified as p-acetylaminophenylacetic acid; norpethidine has also been detected in urine.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose is 0.5 g but it may be up to 5 g in addicts. The following postmortem concentrations were reported in a fatality attributed to oral overdosage of anileridine: blood 0.9 mg/L, bile 2.4 mg/L, urine 11.4 mg/L, vitreous humour 0.07 mg/L; diazepam was also detected. [M. A. Peat and L. Kopjak,Bull. Int. Assoc. Forensic Toxicol.,1979, 14(3), 19.]
- LD50 (rat)N/A
- LD50 (mouse)N/A