- Molecular NameMeloxicam
- SynonymMeloxicamum [latin]
- Weight351.407
- Drugbank_IDDB00814
- ACS_NO71125-38-7
- Show 2D model
- LogP (experiment)3.02
- LogP (predicted, AB/LogP v2.0)2.23
- pkaN/A
- LogD (pH=7, predicted)-0.73
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.66
- LogSw (predicted, AB/LogsW2.0)0.12
- Sw (mg/ml) (predicted, ACD/Labs)0.04
- No.of HBond Donors2
- No.of HBond Acceptors7
- No.of Rotatable Bonds2
- TPSA136.22
- StatusFDA approved
- AdministrationN/A
- PharmacologyA nonsteroidal anti-inflammatory drug of the oxicam class, used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It has been developed by Boehringer-Ingelheim. It is closely related to piroxicam.
- Absorption_value90.0
- Absorption (description)Meloxicam is well absorbed after oral administration reaching maximum concentration 5 to 6 h after once daily dose of 15 mg. After a single 15 mg intramuscular dose, the mean maximum plasma concentration is only about twice that observed after oral administration. Intravenous (IV) administration is associated with a markedly higher initial concentration (intravenous/oral ratio 2.99/0.93) followed by a rapid decline.
- Caco_2-4.71
- Bioavailability89.0
- Protein binding99.4
- Volume of distribution (VD)0.155 L/kg
- Blood/Plasma Partitioning ratio (D_blood)<10% in red blood cells.
- MetabollsmHepatic (CYP2C9 and 3A4-mediated). Meloxicam is extensively metabolised via oxidation and the metabolites (four isolated in total)
- Half life15~18 h
- ExcretionThe metabolites (four isolated in total) (approx. 97% of the dose) are excreted via urine and faeces in equal proportions. Less than 0.5% appears as the unchanged drug in urine. The pharmacokinetics of meloxicam are altered in renal impairment with lower total plasma meloxicam concentration and higher free fractions being observed at creatinine clearance 20 to 40 mL/min. However, there is no apparent risk of increased toxicity.
- Urinary Excretion<1
- Clerance0.11 ml/min/kg
- ToxicityN/A
- LD50 (rat)LD50=84 mg/kg
- LD50 (mouse)LD50=470 mg/kg