• Molecular NameLomefloxacin
  • SynonymLFLX; lomefloxacin hydrochloride; Lomefloxacine [French]; Lomefloxacino [Spanish]; Lomefloxacinum [Latin]
  • Weight351.353
  • Drugbank_IDDB00978
  • ACS_NO98079-51-7
  • Show 3D model
  • LogP (experiment)-0.8
  • LogP (predicted, AB/LogP v2.0)-0.67
  • pkaN/A
  • LogD (pH=7, predicted)-2.9
  • Solubility (experiment)27.2 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.96
  • LogSw (predicted, AB/LogsW2.0)0.4
  • Sw (mg/ml) (predicted, ACD/Labs)0.39
  • No.of HBond Donors2
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds3
  • TPSA72.88
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.
  • Absorption_value99.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability97.0
  • Protein binding10.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life8 h
  • ExcretionUrinary excretion of the compound > 60%
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityAdverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A