- Molecular NamePenicillin_V
- SynonymFenossimetilpenicillina [Dcit]; Fenoximetilpenicilina [INN-Spanish]; Penicillin Phenoxymethyl; Penicillin V Potassium; Phenoximethylpenicillinum; Phenoxymethyl Penicillin; Phenoxymethylenepenicillinic Acid; Phenoxymethylpenicillin Potassium; Phenoxymethylpenicillinic Acid; Phenoxymethylpenicillinic Acid Potassium Salt
- Weight350.395
- Drugbank_IDDB00417
- ACS_NO87-08-01
- Show 3D model
- LogP (experiment)2.09
- LogP (predicted, AB/LogP v2.0)2.02
- pka2.78
- LogD (pH=7, predicted)-1.94
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.46
- LogSw (predicted, AB/LogsW2.0)1.39
- Sw (mg/ml) (predicted, ACD/Labs)0.77
- No.of HBond Donors2
- No.of HBond Acceptors7
- No.of Rotatable Bonds5
- TPSA121.24
- StatusFDA approved
- AdministrationN/A
- PharmacologyThe orally active form of penicillin. It is less active than benzylpenicillin, however, and is appropriate only in conditions where high tissue concentrations are not required. Phenoxymethylpenicillin exerts a bactericidal action against penicillinsensitive microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall Peptidoglycan. It is not active against the Beta-lactamase-producing bacteria, which include many strains of staphylococci.
- Absorption_value59.0
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding80.0
- Volume of distribution (VD)0.5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life30~60 min
- Excretionrenal
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50>1040 mg/kg
- LD50 (mouse)N/A