• Molecular NameAmpicillin
  • SynonymAminobenzylpenicillin; Ampicilina [INN-Spanish]; Ampicillin [Usan:Ban:Inn:Jan]; Ampicillin Acid; Ampicillin Anhydrate; Ampicillin Anhydrous; Ampicillin Base; Ampicillin Sodium; Ampicillin Trihydrate; Ampicillina [Dcit]; Ampicilline; Ampicilline [INN-French]; Ampicillinum [INN-Latin]; Anhydrous Ampicillin; Bayer 5427; D-Ampicillin
  • Weight349.411
  • Drugbank_IDDB00415
  • ACS_NO69-53-4
  • Show 3D model
  • LogP (experiment)-1.13
  • LogP (predicted, AB/LogP v2.0)-0.7
  • pkapKa2.5 (-COOH), 7.3 (-NH2) (25°)
  • LogD (pH=7, predicted)-3.35
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-2.51
  • LogSw (predicted, AB/LogsW2.0)4.29
  • Sw (mg/ml) (predicted, ACD/Labs)0.24
  • No.of HBond Donors4
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds4
  • TPSA138.03
  • StatusFDA approved
  • AdministrationOral, intravenous
  • PharmacologyA beta-lactam antibiotic that has been used extensively to treat bacterial infections since 1961.
  • Absorption_value62.0
  • Absorption (description)Ampicillin is readily but incompletely absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability62.0
  • Protein binding18.0
  • Volume of distribution (VD)0.2 to 0.5 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life1~2 h
  • ExcretionAbout 30% of an oral dose is excreted in the urine in 6 h as unchanged drug and about 10% as penicilloic acid; after parenteral administration about 75% is excreted unchanged in 6 h. High concentrations of ampicillin are attained in the bile.
  • Urinary ExcretionN/A
  • ClerancePlasma clearance, about 3 to 4 mL/min/kg.
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A