NavDB: Sodium Channels Database

NavDB Target ID	NAT008
Name	Sodium channel protein type 10 subunit alpha
Synonyms	Peripheral nerve sodium channel 3 Sodium channel protein type X subunit alpha Voltage-gated sodium channel subunit alpha Nav1.8
Description	Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Organism	Human, Rat, Mouse
UniProt	Q9Y5Y9, Q62968

SOURCE	IDENTIFIER	METHOD	RESOLUTION	ORGANISMS
PDB	7WE4	EM	2.70Å	Homo sapiens
PDB	7WEL	EM	3.20Å	Homo sapiens
PDB	7WFR	EM	3.00Å	Homo sapiens
PDB	7WFW	EM	3.10Å	Homo sapiens
PDB	9DBK	EM	3.12Å	Homo sapiens
PDB	9DBL	EM	3.24Å	Homo sapiens
PDB	9DBM	EM	3.22Å	Homo sapiens
PDB	9DBN	EM	2.76Å	Homo sapiens
AlphaFold3	AF3-Q9Y5Y9-F1	Predicted		Human
AlphaFold3	AF3-Q62968-F1	Predicted		Rat
AlphaFold3	AAF3-Q6QIY3-F1	Predicted		Mouse

NavDB ID	Sructure	ChEMBL ID	Molecular Formula	IC₅₀/EC₅₀* (nM)	Binding Site	Organism	Article DOI