NavDB: Sodium Channels Database

Nav1.7

NavDB Target ID	NAT007
Name	Sodium channel protein type 9 subunit alpha
Synonyms	Neuroendocrine sodium channel Peripheral sodium channel 1 Sodium channel protein type IX subunit alpha Voltage-gated sodium channel subunit alpha Nav1.7
Description	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na⁺ channel isoform.Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Organism	Human, Mouse, Rat
UniProt	Q15858, Q62205, O08562

SOURCE	IDENTIFIER	METHOD	RESOLUTION	ORGANISMS
PDB	6J8G	EM	3.20Å	Homo sapiens
PDB	6J8H	EM	3.20Å	Homo sapiens
PDB	6J8I	EM	3.20Å	Homo sapiens
PDB	6J8J	EM	3.20Å	Homo sapiens
PDB	6NT3	EM	3.40Å	Periplaneta americana, Homo sapiens
PDB	6NT4	EM	3.50Å	Periplaneta americana, Homo sapiens, Androctonus australis
PDB	7W9K	EM	3.20Å	Homo sapiens
PDB	7W9L	EM	3.50Å	Homo sapiens
PDB	7W9M	EM	3.00Å	Homo sapiens
PDB	7W9P	EM	2.90Å	Homo sapiens
PDB	7W9T	EM	3.00Å	Homo sapiens
PDB	7XM9	EM	3.22Å	Homo sapiens, Aequorea victoria
PDB	7XMF	EM	3.07Å	Homo sapiens, Aequorea victoria
PDB	7XMG	EM	3.09Å	Homo sapiens, Aequorea victoria
PDB	7XVE	EM	2.70Å	Homo sapiens
PDB	7XVF	EM	2.80Å	Homo sapiens
PDB	8G1A	EM	2.80Å	Homo sapiens
PDB	8I5B	EM	2.70Å	Homo sapiens
PDB	8I5G	EM	2.70Å	Homo sapiens
PDB	8I5X	EM	2.90Å	Homo sapiens
PDB	8I5Y	EM	2.60Å	Homo sapiens
PDB	8J4F	EM	3.00Å	Homo sapiens
PDB	8S9B	EM	2.90Å	Homo sapiens
PDB	8S9C	EM	3.20Å	Homo sapiens
PDB	8THG	EM	2.90Å	Homo sapiens
PDB	8THH	EM	2.70Å	Homo sapiens
PDB	8XMM	EM	2.89Å	Homo sapiens
PDB	8XMN	EM	3.37Å	Homo sapiens
PDB	8XMO	EM	3.39Å	Homo sapiens
PDB	5EK0	X-ray	3.53Å	Arcobacter butzleri RM4018, Homo sapiens
PDB	8F0P	EM	2.20Å	Homo sapiens, Periplaneta americana
PDB	8F0Q	EM	2.50Å	Homo sapiens, Periplaneta americana
PDB	8F0R	EM	2.90Å	Homo sapiens, Periplaneta americana
PDB	8F0S	EM	3.10Å	Homo sapiens, Periplaneta americana
PDB	9ITI	EM	2.92Å	Homo sapiens
AlphaFold3	AF3-Q15858-F1	Predicted		Human
AlphaFold3	AF3-O08562-F1	Predicted		Rat
AlphaFold3	AF3-Q62205-F1	Predicted		Mouse

Compounds	xlsx CSV SDF

NavDB ID	Sructure	ChEMBL ID	Molecular Formula	IC₅₀/EC₅₀* (nM)	Binding Site	Organism	Article DOI