Nav1.6

Target Information
NavDB Target ID NAT006
Name Sodium channel protein type 8 subunit alpha
Synonyms
  • Sodium channel protein type VIII subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.6
Description Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Organism Human, Mouse, Rat
UniProt Q9UQD0, Q9WTU3
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
PDB 8GZ1 EM 3.40Å Homo sapiens
PDB 8GZ2 EM 3.30Å Homo sapiens
PDB 8FHD EM 3.10Å Homo sapiens
PDB 9DK5 EM 2.90Å Homo sapiens
AlphaFold3 AF3-Q9UQD0-F1 Predicted Human
AlphaFold3 AF3-Q9WTU3-F1 Predicted Mouse
AlphaFold3 AF3-O88420-F1 Predicted Rat
Compounds
NavDB ID Sructure ChEMBL ID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI

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