Nav1.5

Target Information
NavDB Target ID NAT005
Name Sodium channel protein type 5 subunit alpha
Synonyms
  • Sodium channel protein cardiac muscle subunit alpha
  • Sodium channel protein type V subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.5
Description This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
Organism Human, Rat, Mouse
UniProt Q14524
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
PDB 6LQA EM 3.30Å Homo sapiens
PDB 7DTC EM 3.30Å Homo sapiens
PDB 8VYJ EM 3.60Å Homo sapiens
PDB 6UZ0 EM 3.24Å Rattus norvegicus, Aequorea victoria
PDB 6UZ3 EM 3.50Å Rattus norvegicus, Aequorea victoria
PDB 7FBS EM 3.40Å Rattus norvegicus, Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP
PDB 7XSU EM 3.40Å Rattus norvegicus, Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP
PDB 8F6P EM 3.20Å Rattus norvegicus, Aequorea victoria
PDB 8T6L EM 3.30Å Rattus norvegicus, Aequorea victoria
PDB 8VYJ EM 3.60Å Homo sapiens
PDB 8VYK EM 3.90Å Homo sapiens
PDB 9ITH EM 3.40Å Homo sapiens
AlphaFold3 AF3-Q14524-F1 Predicted Human
AlphaFold3 AF3-P15389-F1 Predicted Rat
AlphaFold3 AF3-Q9JJV9-F1 Predicted Mouse
Compounds
xlsx CSV SDF
NavDB ID Sructure ChEMBL ID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI

Copyright © 2025-2027 Tingjun Hou's Group All Right Reserved