Nav1.4

Target Information
NavDB Target ID NAT004
Name Sodium channel protein type 4 subunit alpha
Synonyms
  • Sodium channel protein skeletal muscle subunit alpha
  • Sodium channel protein type IV subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.4
Description Pore-forming subunit of a voltage-gated sodium channel complex through which Na+ ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states.Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K+ levels.
Organism Human, Mouse, Rat
UniProt P35499, Q9ER60, P15390
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
PDB 6AGF EM 3.20Å Homo sapiens
PDB 5XSY EM 4.00Å Electrophorus electricus
AlphaFold3 AF3-P15390-F1 Predicted Rat
AlphaFold3 AF3-P35499-F1 Predicted Human
AlphaFold3 AF3-Q9ER60-F1 Predicted Mouse
Compounds
NavDB ID Sructure ChEMBL ID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI

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