NavDB: Sodium Channels Database

NavDB Target ID	NAT001
Name	Sodium channel protein type 1 subunit alpha
Synonyms	Sodium channel protein brain I subunit alpha Sodium channel protein type I subunit alpha Voltage-gated sodium channel subunit alpha Nav1.1
Description	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.
Organism	Human, Rat, Mouse
UniProt	P35498, P04774

SOURCE	IDENTIFIER	METHOD	RESOLUTION	ORGANISMS
PDB	7DTD	EM	3.30Å	Homo sapiens
AlphaFold3	AF3-P04774-F1	Predicted		Rat
AlphaFold3	AF3-P35498-F1	Predicted		Human
AlphaFold3	AF3-A2APX8-F1	Predicted		Mouse

NavDB ID	Sructure	ChEMBL ID	Molecular Formula	IC₅₀/EC₅₀* (nM)	Binding Site	Organism	Article DOI