This drug-target network shows not only the relationships between individual targets but also the relationships between individual targets and kinase inhibitors of other targets. The shade of the node represents the size of the target's connection with other targets, and the shade of the edge represents the amount of kinase inhibitors shared with other targets. Detailed net data and shared kinase inhibitors can be downloaded here.
Protein Kinase | Classfication | Num_PDB | PDB Files | Num_SMILES | PKI SMILES |
---|---|---|---|---|---|
ABL1 | TK | 43 | Download | 1331 | Download |
ALK1 | TK | 47 | Download | 1502 | Download |
AKT1 | TK | 51 | Download | 407 | Download |
AURKA | Others | 105 | Download | 1189 | Download |
BRAF | TKL | 65 | Download | 1143 | Download |
BTK | TK | 74 | Download | 5537 | Download |
CDK2 | TK | 172 | Download | 1179 | Download |
CHEK1 | TK | 130 | Download | 1065 | Download |
CK2 | CMGG | 124 | Download | 596 | Download |
C-MET | TK | 77 | Download | 2373 | Download |
EGFR | TK | 131 | Download | 4068 | Download |
EPHA2 | TK | 45 | Download | 533 | Download |
FGFR1 | TK | 40 | Download | 1740 | Download |
GSK3b | CMGG | 61 | Download | 837 | Download |
IRAK4 | TKL | 51 | Download | 2265 | Download |
JAK1 | TK | 39 | Download | 3567 | Download |
JAK2 | TK | 98 | Download | 3199 | Download |
KDR | TK | 62 | Download | 3427 | Download |
MAP2K1 | STE | 49 | Download | 736 | Download |
MAPK1 | CMGG | 113 | Download | 3002 | Download |
MAPK14 | TK | 189 | Download | 2559 | Download |
PI3Kg | AGC | 103 | Download | 650 | Download |
SYK | TK | 59 | Download | 642 | Download |