- Molecular NameAminocaproic Acid
- Synonym6-aminohexanoic acid; ACS; Aminocaproate; Aminocaproic; aminocaproic acid; E-aminocaproic acid; ε-Ahx; ε-amino caproic acid
- Weight131.175
- Drugbank_IDDB00513
- ACS_NO60-32-2
- Show 3D model
- LogP (experiment)-1.53
- LogP (predicted, AB/LogP v2.0)-2.8
- pka4.4, 10.8
- LogD (pH=7, predicted)-5.3
- Solubility (experiment)505 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.24
- LogSw (predicted, AB/LogsW2.0)796.73
- Sw (mg/ml) (predicted, ACD/Labs)74.85
- No.of HBond Donors3
- No.of HBond Acceptors3
- No.of Rotatable Bonds5
- TPSA63.32
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn effective inhibitor for enzymes that bind that particular residue. It is effective in treatment of some bleeding disorders and is marketed as Amicar.
- Absorption_valueN/A
- Absorption (description)Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)0.4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmSixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.
- Half life2~5 h
- ExcretionAbout 70 to 80% of a dose is excreted in the urine unchanged in 12 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityA few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
- LD50 (rat)N/A
- LD50 (mouse)N/A