• Molecular NameFluorouracil
  • SynonymNA
  • Weight130.078
  • Drugbank_IDDB00544
  • ACS_NO51-21-8
  • Show 3D model
  • LogP (experiment)-0.77
  • LogP (predicted, AB/LogP v2.0)-0.71
  • pka8.0, 13.0
  • LogD (pH=7, predicted)-0.77
  • Solubility (experiment)12.4 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.21
  • LogSw (predicted, AB/LogsW2.0)3.59
  • Sw (mg/ml) (predicted, ACD/Labs)16.88
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds0
  • TPSA58.2
  • StatusFDA approved
  • AdministrationIntravenous (infusion or bolus) and topical
  • PharmacologyA pyrimidine analog which is used in the treatment of cancer. It works through the inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability28.0
  • Protein binding10.0
  • Volume of distribution (VD)0.25 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIntracellular and hepatic (CYP-mediated)
  • Half life11 min
  • ExcretionRenal
  • Urinary Excretion<10
  • Clerance16 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=230mg/kg