- Molecular NameMetformin
- SynonymMetformin HCL; metformin hydrochloride
- Weight129.167
- Drugbank_IDDB00331
- ACS_NO657-24-9
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-1.3
- pka2.8, 11.5
- LogD (pH=7, predicted)-4.4
- Solubility (experiment)Soluble as HCl salt
- LogS (predicted, ACD/Labs)(ph=7)0.89
- LogSw (predicted, AB/LogsW2.0)2.48
- Sw (mg/ml) (predicted, ACD/Labs)1000.0
- No.of HBond Donors5
- No.of HBond Acceptors5
- No.of Rotatable Bonds3
- TPSA88.99
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn oral anti-diabetic drug.
- Absorption_value54.0
- Absorption (description)Absorbed over 6 hours, bioavailability is 50 to 60% under fasting conditions. Food delays absorption.
- Caco_2N/A
- Bioavailability52.0
- Protein binding0.0
- Volume of distribution (VD)1.12 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetformin is not metabolized.
- Half life1.74 h
- ExcretionAbout 30 to 50% of an oral dose is excreted in the urine as unchanged drug in 24 h, and about 30% of the dose is eliminated unchanged in the faeces.
- Urinary Excretion99.9
- Clerance7.62 ml/min/kg
- ToxicityIt would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.
- LD50 (rat)N/A
- LD50 (mouse)N/A