- Molecular NameFlucytosine
- Synonym5-FC; 5-Fluorocystosine; 5-Fluorocytosin; 5-Fluorocytosine; 5-Flurocytosine; Flucytosin; Fluocytosine; Fluorcytosine
- Weight129.094
- Drugbank_IDDB01099
- ACS_NO2022-85-7
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-1.21
- pka2.9, 10.7
- LogD (pH=7, predicted)-1.21
- Solubility (experiment)10.5 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.4
- LogSw (predicted, AB/LogsW2.0)6.99
- Sw (mg/ml) (predicted, ACD/Labs)50.97
- No.of HBond Donors3
- No.of HBond Acceptors4
- No.of Rotatable Bonds0
- TPSA67.48
- StatusFDA approved
- AdministrationOral, intravenous
- PharmacologyA synthetic antimycotic drug.
- Absorption_value100.0
- Absorption (description)Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.
- Caco_2N/A
- Bioavailability84.0
- Protein binding29.5
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMinimal, in the GI tract
- Half life2.4~4.8 h
- ExcretionRenal (90%)
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50 = >15 gm/kg.
- LD50 (mouse)N/A