- Molecular NameMethimazole
- SynonymMercaptazole; Mercasolyl; Mercazole; Mercazolyl; Merkazolil; Metazolo; Methamazole; Methiamazole; Methimazol; Metothyrin; Metothyrine; Thiamazol; Thiamazole; Thimazole; Thymidazol; Thymidazole
- Weight114.172
- Drugbank_IDDB00763
- ACS_NO60-56-0
- Show 3D model
- LogP (experiment)-0.34
- LogP (predicted, AB/LogP v2.0)-0.07
- pkaN/A
- LogD (pH=7, predicted)-0.07
- Solubility (experiment)275 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.36
- LogSw (predicted, AB/LogsW2.0)18.08
- Sw (mg/ml) (predicted, ACD/Labs)49.95
- No.of HBond Donors1
- No.of HBond Acceptors2
- No.of Rotatable Bonds0
- TPSA47.36
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn antithyroid drug
- Absorption_value95.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability93.0
- Protein binding0.0
- Volume of distribution (VD)0.7 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmPrimarily hepatic. Metabolized rapidly, requiring frequent administration.
- Half life5~6 h
- ExcretionRenal
- Urinary ExcretionN/A
- Clerance3 ml/min/kg
- ToxicitySymptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
- LD50 (rat)LD50=2250 mg/kg
- LD50 (mouse)N/A