- Molecular NameDimethyl sulfoxide
- SynonymDiemthyl sulfoxide; Dimethyl sulfoxide BP; Dimethyl sulfur oxide; Dimethyl sulphoxide; Dimethyl sulpoxide; Dimexidum; Methyl sulfoxide; Methylsulfinylmethane; Sulfinylbis-methane; Sulfinylbismethane; Sulfinyldimethane
- Weight78.135
- Drugbank_IDDB01093
- ACS_NO67-68-5
- Show 2D model
- LogP (experiment)-1.35
- LogP (predicted, AB/LogP v2.0)-0.8
- pkaN/A
- LogD (pH=7, predicted)-0.8
- Solubility (experiment)253 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)1.11
- LogSw (predicted, AB/LogsW2.0)45.68
- Sw (mg/ml) (predicted, ACD/Labs)1000.0
- No.of HBond Donors0
- No.of HBond Acceptors1
- No.of Rotatable Bonds0
- TPSA36.28
- StatusFDA approved
- AdministrationN/A
- PharmacologyDMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions. Without it, up to 90 percent of frozen cells will become inactive.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after injection or after oral or percutaneous administration. Widely distributed throughout the body.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is oxidised to dimethyl sulfone.
- Half lifeN/A
- ExcretionAfter an oral dose, about 30 to 70% is excreted in the urine unchanged and about 20% as the sulfone; after percutaneous administration, about 13% is excreted unchanged and about 18% as the sulfone; about 3% of a dose is eliminated through the lungs as dimethyl sulfide.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityDimethyl sulfoxide has low systemic toxicity, but gives local toxic effects.
- LD50 (rat)N/A
- LD50 (mouse)N/A