- Molecular NameAcetohydroxamic Acid
- SynonymAcethydroxamsaure; Acetic acid; oxime; Acetohydroxamate; Acetohydroximic acid; Acetyl hydroxyamino; Acetylhydroxamic acid; AHA; Cetohyroxamic acid; Methylhydroxamic acid; N-Hydroxyacetamide
- Weight75.067
- Drugbank_IDDB00551
- ACS_NO546-88-3
- Show 2D model
- LogP (experiment)-0.567
- LogP (predicted, AB/LogP v2.0)-1.23
- pka8.7
- LogD (pH=7, predicted)-1.23
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)1.12
- LogSw (predicted, AB/LogsW2.0)258.88
- Sw (mg/ml) (predicted, ACD/Labs)1000.0
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds0
- TPSA49.33
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections.
- Absorption_valueN/A
- Absorption (description)Well absorbed from the GI tract following oral administration.
- Caco_2N/A
- Bioavailability55.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsm35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).
- Half life3.5~10 h
- ExcretionApproximately 35–65% of an orally administered dose is excreted unchanged in urine within 24–48 hours in patients with normal renal function; less than 10% is excreted in urine as acetamide.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityOral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.
- LD50 (rat)N/A
- LD50 (mouse)N/A