• Molecular NameEthanol
  • SynonymN/A
  • Weight46.0684
  • Drugbank_IDDB00898
  • ACS_NO64-17-5
  • Show 3D model
  • LogP (experiment)-0.3
  • LogP (predicted, AB/LogP v2.0)-0.31
  • pka15.9
  • LogD (pH=7, predicted)-0.31
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.6
  • LogSw (predicted, AB/LogsW2.0)292.59
  • Sw (mg/ml) (predicted, ACD/Labs)183.87
  • No.of HBond Donors1
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds0
  • TPSA20.23
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyOne of the oldest recreational drugs. In common usage, it is often referred to simply as alcohol or spirits.
  • Absorption_value100.0
  • Absorption (description)Readily absorbed from the stomach and small intestine after oral administration but absorption may be delayed by the presence of food; rapidly distributed throughout the body fluids.
  • Caco_20.0
  • Bioavailability80.0
  • Protein binding0.0
  • Volume of distribution (VD)0.6 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, 1.2.
  • MetabollsmMetabolised in the liver by alcohol dehydrogenase to acetaldehyde and then further oxidised to acetate and carbon dioxide.
  • Half lifedose-dependent.
  • ExcretionMore than 90% is metabolised and is excreted by the lungs and in the urine, saliva, sweat and other secretions together with unchanged alcohol. The body can metabolise about 10 to 15 mL per hour. The rate of metabolism may be accelerated following repeated excessive use.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe minimum lethal dose is about 500 mL of 50% spirit ingested in about 1 h. In the UK it is illegal to be in charge of a motor vehicle with a concentration greater than 800 mg/L in the blood or 1070 mg/L in the urine or 0.35 mg/L in the breath. Toxic effects are associated with blood concentrations of 840 to 2400 to 4500 mg/L, and subjects with concentrations of 3000 mg/L or more are considered to be clinically drunk. Blood concentrations of 2250 to 4000 to 6030 mg/L have been associated with fatalities. The maximum permissible atmospheric concentration is 1000 ppm.
  • LD50 (rat)LD(50)=5628 mg/kg
  • LD50 (mouse)N/A