• Molecular NameInsulin
  • SynonymNA
  • Weight5777.64
  • Drugbank_IDDB01383
  • ACS_NO9004-10-8
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)N/A
  • pkaN/A
  • LogD (pH=7, predicted)N/A
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)N/A
  • LogSw (predicted, AB/LogsW2.0)N/A
  • Sw (mg/ml) (predicted, ACD/Labs)N/A
  • No.of HBond DonorsN/A
  • No.of HBond AcceptorsN/A
  • No.of Rotatable BondsN/A
  • TPSAN/A
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA hormone that has extensive effects on metabolism and other body functions, such as vascular compliance.
  • Absorption_valueN/A
  • Absorption (description)Ineffective after oral administration owing to rapid inactivation by proteolytic enzymes, but well absorbed after subcutaneous or intramuscular injection. The rate of absorption from different sites depends on local blood flow; absorption from the abdomen being faster than that from the arm and that from the arm, faster than from either the thigh or buttock.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding5.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmAbout 50% of endogenous insulin in the portal vein is metabolised in a single passage through the liver. It is reduced to two separate chains by glutathione insulin transhydrogenase. The intact molecule or reduced chains may be metabolised by insulin-specific protease to peptides and amino acids.
  • Half life5~6 min in normal subjects, but may be longer in diabetics who develop anti-insulin antibodies.
  • ExcretionInsulin is filtered at the glomeruli but is reabsorbed and metabolised in the renal tubules, and only small amounts are excreted unchanged in the urine. It is also excreted in the bile.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A