• Molecular NamePhenylephrine
  • SynonymFenilefrina [INN-Spanish]; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasynephrine; Phenylephrinum [INN-Latin
  • Weight167.208
  • Drugbank_IDDB00388
  • ACS_NO59-42-7
  • Show 3D model
  • LogP (experiment)-0.31
  • LogP (predicted, AB/LogP v2.0)-0.31
  • pka8.9 (COH), 10.1 (CNH–)
  • LogD (pH=7, predicted)-2.51
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.78
  • LogSw (predicted, AB/LogsW2.0)27.97
  • Sw (mg/ml) (predicted, ACD/Labs)39.32
  • No.of HBond Donors3
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds3
  • TPSA52.49
  • StatusFDA approved
  • AdministrationOral, intranasal, ophthalmic, intravenous, intramuscular
  • PharmacologyAn α1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability35.0
  • Protein binding95.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (monoamine oxidase)
  • Half life2~3 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityHeadache, reflex bradycardia, excitability, restlessness, and rarely arrhythmias.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A