- Molecular NamePhenylephrine
- SynonymFenilefrina [INN-Spanish]; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasynephrine; Phenylephrinum [INN-Latin
- Weight167.208
- Drugbank_IDDB00388
- ACS_NO59-42-7
- Show 3D model
- LogP (experiment)-0.31
- LogP (predicted, AB/LogP v2.0)-0.31
- pka8.9 (COH), 10.1 (CNH–)
- LogD (pH=7, predicted)-2.51
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.78
- LogSw (predicted, AB/LogsW2.0)27.97
- Sw (mg/ml) (predicted, ACD/Labs)39.32
- No.of HBond Donors3
- No.of HBond Acceptors3
- No.of Rotatable Bonds3
- TPSA52.49
- StatusFDA approved
- AdministrationOral, intranasal, ophthalmic, intravenous, intramuscular
- PharmacologyAn α1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability35.0
- Protein binding95.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic (monoamine oxidase)
- Half life2~3 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityHeadache, reflex bradycardia, excitability, restlessness, and rarely arrhythmias.
- LD50 (rat)N/A
- LD50 (mouse)N/A