- Molecular NameThioguanine
- Synonym2-Amino 6MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-purinethiol; 2-Aminopurin-6-thiol; 2-Aminopurine-6-thiol; 2-Aminopurine-6(1H)-thione; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-Thioguanine; TG; ThG; Tioguanin; Tioguanine
- Weight167.196
- Drugbank_IDDB00352
- ACS_NO154-42-7
- Show 3D model
- LogP (experiment)-0.07
- LogP (predicted, AB/LogP v2.0)0.07
- pkaN/A
- LogD (pH=7, predicted)0.04
- Solubility (experiment)36.3 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.78
- LogSw (predicted, AB/LogsW2.0)0.36
- Sw (mg/ml) (predicted, ACD/Labs)0.28
- No.of HBond Donors4
- No.of HBond Acceptors5
- No.of Rotatable Bonds0
- TPSA111.18
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug that is used in the treatment of cancer.
- Absorption_value30.0
- Absorption (description)Absorption of an oral dose is incomplete and variable, averaging approximately 30% of the administered dose (range: 14% to 46%)
- Caco_2N/A
- Bioavailability30.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic. First converted to 6-thioguanilyic acid (TGMP). TGMP is further converted to the di- and tri-phosphates, thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP) by the same enzymes that metabolize guanine nucleotides.
- Half life80 min (range 25-240 minutes)
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include nausea, vomiting, malaise, hypotension, and diaphoresis.
- LD50 (rat)N/A
- LD50 (mouse)LD50=160 mg/kg