• Molecular NameThioguanine
  • Synonym2-Amino 6MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-purinethiol; 2-Aminopurin-6-thiol; 2-Aminopurine-6-thiol; 2-Aminopurine-6(1H)-thione; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-Thioguanine; TG; ThG; Tioguanin; Tioguanine
  • Weight167.196
  • Drugbank_IDDB00352
  • ACS_NO154-42-7
  • Show 3D model
  • LogP (experiment)-0.07
  • LogP (predicted, AB/LogP v2.0)0.07
  • pkaN/A
  • LogD (pH=7, predicted)0.04
  • Solubility (experiment)36.3 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.78
  • LogSw (predicted, AB/LogsW2.0)0.36
  • Sw (mg/ml) (predicted, ACD/Labs)0.28
  • No.of HBond Donors4
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds0
  • TPSA111.18
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA drug that is used in the treatment of cancer.
  • Absorption_value30.0
  • Absorption (description)Absorption of an oral dose is incomplete and variable, averaging approximately 30% of the administered dose (range: 14% to 46%)
  • Caco_2N/A
  • Bioavailability30.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic. First converted to 6-thioguanilyic acid (TGMP). TGMP is further converted to the di- and tri-phosphates, thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP) by the same enzymes that metabolize guanine nucleotides.
  • Half life80 min (range 25-240 minutes)
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include nausea, vomiting, malaise, hypotension, and diaphoresis.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=160 mg/kg