- Molecular NamePseudoephedrine
- SynonymNA
- Weight165.236
- Drugbank_IDDB00852
- ACS_NO90-82-4
- Show 3D model
- LogP (experiment)0.9
- LogP (predicted, AB/LogP v2.0)1.05
- pka9.8
- LogD (pH=7, predicted)-1.27
- Solubility (experiment)Slightly soluble
- LogS (predicted, ACD/Labs)(ph=7)0.78
- LogSw (predicted, AB/LogsW2.0)80.66
- Sw (mg/ml) (predicted, ACD/Labs)38.66
- No.of HBond Donors2
- No.of HBond Acceptors2
- No.of Rotatable Bonds3
- TPSA32.26
- StatusFDA approved
- AdministrationN/A
- PharmacologyA sympathomimetic drug of the phenethylamine and amphetamine chemical classes used as a nasal/sinus decongestant and stimulant or wakefulness-promoting agent.
- Absorption_value100.0
- Absorption (description)Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
- Caco_2N/A
- Bioavailability100.0
- Protein bindingN/A
- Volume of distribution (VD)3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmPseudoephedrine is extensively reabsorbed
- Half life4.3~8 h
- Excretion70-90% renal
- Urinary Excretion43~96
- Clerance7.33 ml/min/kg
- ToxicityCommon adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
- LD50 (rat)N/A
- LD50 (mouse)N/A