- Molecular NameEphedrine
- SynonymNA
- Weight165.236
- Drugbank_IDDB01364
- ACS_NO50906-05-3
- Show 3D model
- LogP (experiment)0.93
- LogP (predicted, AB/LogP v2.0)1.05
- pka9.6
- LogD (pH=7, predicted)-1.27
- Solubility (experiment)56 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.78
- LogSw (predicted, AB/LogsW2.0)80.66
- Sw (mg/ml) (predicted, ACD/Labs)38.66
- No.of HBond Donors2
- No.of HBond Acceptors2
- No.of Rotatable Bonds3
- TPSA32.26
- StatusFDA approved
- Administrationoral, IV, IM, SC
- PharmacologyA sympathomimetic amine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral or percutaneous administration.
- Caco_2N/A
- Bioavailability85.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised by N-demethylation to norephedrine (phenylpropanolamine) and by oxidative deamination followed by conjugation. Accumulates in the liver, lungs, kidneys, spleen, and brain.
- Half life3~6 h but may be increased when the urine is alkaline and decreased when it is acid.
- ExcretionAbout 90% of a dose is excreted in the urine in 24 h, with about 55 to 75% of the dose as unchanged drug, 8 to 20% as norephedrine, and 4 to 13% as deaminated metabolites such as benzoic acid, hippuric acid, and 1-phenylpropane-1,2-diol. In acidic urine, excretion of unchanged drug is increased slightly, whereas, in alkaline urine, about 20 to 35% of the dose is excreted unchanged and the proportion of norephedrine is increased. Ephedrine is a metabolite of methylephedrine.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose in children up to 2 years of age is 200 mg and for adults 2 g but fatalities are rare. Single doses of up to 400 mg have been given without causing serious toxic effects.
- LD50 (rat)N/A
- LD50 (mouse)N/A