- Molecular NameBenzocaine
- SynonymEthyl Aminobenzoate; Ethyl P-Aminobenzoate; Ethyl P-Aminophenylcarboxylate; Ethylester Kyseliny P-Aminobenzoove; P-Aminobenzoic Acid, Ethyl Ester; P-Carbethoxyaniline; P-Ethoxycarboxylic Aniline
- Weight165.192
- Drugbank_IDDB01086
- ACS_NO94-09-7
- Show 3D model
- LogP (experiment)1.86
- LogP (predicted, AB/LogP v2.0)1.79
- pka2.5
- LogD (pH=7, predicted)1.79
- Solubility (experiment)0.791 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.04
- LogSw (predicted, AB/LogsW2.0)2.94
- Sw (mg/ml) (predicted, ACD/Labs)1.52
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds3
- TPSA52.32
- StatusFDA approved
- AdministrationTopical
- PharmacologyA local anesthetic commonly used as a topical pain reliever.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmBenzocaine is metabolised by hydrolysis to 4-aminobenzoic acid. At the concentrations normally used (2 to 10%) it is comparatively non-irritant and non-toxic, having only about one-tenth the toxicity of cocaine. The maximum safe amount for topical use is 5000 mg (25 mL of a 20% solution).
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLD50=3040 mg/kg (rat, oral)
- LD50 (rat)N/A
- LD50 (mouse)N/A