• Molecular NameBenzocaine
  • SynonymEthyl Aminobenzoate; Ethyl P-Aminobenzoate; Ethyl P-Aminophenylcarboxylate; Ethylester Kyseliny P-Aminobenzoove; P-Aminobenzoic Acid, Ethyl Ester; P-Carbethoxyaniline; P-Ethoxycarboxylic Aniline
  • Weight165.192
  • Drugbank_IDDB01086
  • ACS_NO94-09-7
  • Show 3D model
  • LogP (experiment)1.86
  • LogP (predicted, AB/LogP v2.0)1.79
  • pka2.5
  • LogD (pH=7, predicted)1.79
  • Solubility (experiment)0.791 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.04
  • LogSw (predicted, AB/LogsW2.0)2.94
  • Sw (mg/ml) (predicted, ACD/Labs)1.52
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds3
  • TPSA52.32
  • StatusFDA approved
  • AdministrationTopical
  • PharmacologyA local anesthetic commonly used as a topical pain reliever.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmBenzocaine is metabolised by hydrolysis to 4-aminobenzoic acid. At the concentrations normally used (2 to 10%) it is comparatively non-irritant and non-toxic, having only about one-tenth the toxicity of cocaine. The maximum safe amount for topical use is 5000 mg (25 mL of a 20% solution).
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityLD50=3040 mg/kg (rat, oral)
  • LD50 (rat)N/A
  • LD50 (mouse)N/A