• Molecular NameMethoxyflurane
  • SynonymMethoflurane; Methoxiflurane; Methoxifluranum; Methoxyfluoran; Methoxyfluorane; Methoxyfluran; Methoxyfluranum [INN-Latin]; Metossiflurano [Dcit]; Metoxfluran; Metoxifluran; Metoxiflurano [INN-Spanish]; MOF
  • Weight164.966
  • Drugbank_IDDB01028
  • ACS_NO76-38-0
  • Show 3D model
  • LogP (experiment)2.2
  • LogP (predicted, AB/LogP v2.0)2.09
  • pkaN/A
  • LogD (pH=7, predicted)2.09
  • Solubility (experiment)2 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.19
  • LogSw (predicted, AB/LogsW2.0)2.48
  • Sw (mg/ml) (predicted, ACD/Labs)10.64
  • No.of HBond Donors0
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds2
  • TPSA9.23
  • StatusFDA approved
  • AdministrationInhalation
  • PharmacologyUsed as an inhalational anaesthetic in the 1960s and early 1970s. The clinical use of methoxyflurane in human medicine has largely been abandoned because of detrimental effects on the kidneys. This was due to fluoride ions being produced by its metabolism in the kidney.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
  • LD50 (rat)LD50=3600 mg/kg
  • LD50 (mouse)N/A