- Molecular NameMephentermine
- SynonymMefenterdrin; Mefentermin; Mephenterdrine; Mephenterdrinum; Mephetedrine; N-methylphentermine
- Weight163.264
- Drugbank_IDDB01365
- ACS_NO100-92-5
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)2.65
- pka10.4
- LogD (pH=7, predicted)-0.23
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)0.79
- LogSw (predicted, AB/LogsW2.0)1.16
- Sw (mg/ml) (predicted, ACD/Labs)4.07
- No.of HBond Donors1
- No.of HBond Acceptors1
- No.of Rotatable Bonds3
- TPSA12.03
- StatusFDA approved
- Administrationparenterally
- PharmacologyA cardiac stimulant. It was formerly used in Wyamine nasal decongestant inhalers and before that as a stimulant in psychiatry.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral or parenteral administration
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmRapidly metabolised by demethylation and hydroxylation.
- Half lifeDerived from urinary excretion data, about 6 to 20 h
- ExcretionAbout 50 to 85% of a dose is excreted in the urine unchanged, together with 15 to 20% as phentermine. Conjugated N-hydroxymephentermine has also been detected in the urine in small quantities.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose in children up to 2 years of age is 200 mg, and in adults is 2 g.
- LD50 (rat)N/A
- LD50 (mouse)N/A