- Molecular NameAcetylcysteine
- SynonymN-acetylcysteine; NAC
- Weight163.197
- Drugbank_IDDB06151
- ACS_NO616-91-1
- Show 3D model
- LogP (experiment)-0.29
- LogP (predicted, AB/LogP v2.0)-1.47
- pka4, 9.5
- LogD (pH=7, predicted)-5.21
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.79
- LogSw (predicted, AB/LogsW2.0)61.83
- Sw (mg/ml) (predicted, ACD/Labs)57.72
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds3
- TPSA105.2
- StatusFDA approved
- AdministrationInhalation, IV, oral
- PharmacologyA pharmaceutical drug used mainly as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability5.0
- Protein binding78.0
- Volume of distribution (VD)25.5 L (healthy subjects); 17.4 L (patients with cirrhosis)
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic. Acetylcysteine is primarily metabolised to cysteine.
- Half life2.6 h (healthy subjects); 4.9 h (patients with cirrhosis).
- ExcretionAbout 20% of a dose is excreted in the urine in 24 h.
- Urinary ExcretionN/A
- CleranceBody, 6.5 L/h (healthy subjects); 4.5 L/h (patients with cirrhosis).
- ToxicitySingle intravenous doses of acetylcysteine at 1000 mg/kg in mice, 2445 mg/kg in rats, 1500 mg/kg in guinea pigs, 1200 mg/kg in rabbits and 500 mg/kg in dogs were lethal. Symptoms of acute toxicity were ataxia, hypoactivity, labored respiration, cyanosis, loss of righting reflex and convulsions.
- LD50 (rat)N/A
- LD50 (mouse)N/A