• Molecular NameMenthol
  • Synonym(-)-menthol; (r)-(-)-menthol; L-(-)-menthol; L-menthol; Levomenthol
  • Weight156.269
  • Drugbank_IDDB00825
  • ACS_NO89-78-1
  • Show 3D model
  • LogP (experiment)3.4
  • LogP (predicted, AB/LogP v2.0)3.18
  • pkaN/A
  • LogD (pH=7, predicted)3.18
  • Solubility (experiment)0.714 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.03
  • LogSw (predicted, AB/LogsW2.0)0.49
  • Sw (mg/ml) (predicted, ACD/Labs)1.47
  • No.of HBond Donors1
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds1
  • TPSA20.23
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyMenthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak kappa Opioid receptor agonist.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionMenthol is excreted in the bile and urine as a glucuronide conjugate; the various stereoisomers differ quantitatively in the extent to which they conjugate with glucuronic acid. Menthol may occur in the conjugated form as a metabolite of pulagone which is a constituent of pulegium oil.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe minimum lethal dose has been estimated to be about 2 g. The application of drops or ointments containing menthol to the nostrils of infants is dangerous and may cause instant collapse. Ingestion of excess menthol may cause severe abdominal pain and coma.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A