- Molecular NameDopamine
- SynonymDA; Deoxyepinephrine; Dopamin; Dopamine HCl; Dophamine; Hydroxytyramin; Hydroxytyramine; Oxytyramine
- Weight153.181
- Drugbank_IDDB00988
- ACS_NO51-61-6
- Show 3D model
- LogP (experiment)0.548
- LogP (predicted, AB/LogP v2.0)0.14
- pka8.8, 10.6
- LogD (pH=7, predicted)-1.46
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.64
- LogSw (predicted, AB/LogsW2.0)13.11
- Sw (mg/ml) (predicted, ACD/Labs)9.17
- No.of HBond Donors4
- No.of HBond Acceptors3
- No.of Rotatable Bonds2
- TPSA66.48
- StatusFDA approved
- AdministrationN/A
- PharmacologyA neurotransmitter that occurs in a wide variety of animals, including both vertebrates and invertebrates.
- Absorption_valueN/A
- Absorption (description)Dopamine is a naturally occurring catecholamine and is considered to be the metabolic precursor of noradrenaline. It is inactivated after oral administration.
- Caco_2N/A
- Bioavailability20.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is excreted mainly as 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid); noradrenaline (norepinephrine) and 3-methoxytyramine are also metabolites. Dopamine is a metabolite of levodopa.
- Half life2 min
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySpasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.
- LD50 (rat)1780 mg/kg
- LD50 (mouse)1460 mg/kg