- Molecular NameMercaptopurine
- Synonym6 MP; 6-Mercaptopurine; Mercaptopurine Monohydrate; Mercapurin; MP
- Weight152.181
- Drugbank_IDDB01033
- ACS_NO50-44-2
- Show 3D model
- LogP (experiment)0.0
- LogP (predicted, AB/LogP v2.0)0.53
- pka7.7, 11.0
- LogD (pH=7, predicted)0.44
- Solubility (experiment)0.25 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.98
- LogSw (predicted, AB/LogsW2.0)0.32
- Sw (mg/ml) (predicted, ACD/Labs)1.58
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds0
- TPSA85.16
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn immunosuppressive drug. It is a thiopurine.
- Absorption_value50.0
- Absorption (description)Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
- Caco_2N/A
- Bioavailability12.0
- Protein binding19.0
- Volume of distribution (VD)0.56 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmXanthine oxidase. It is metabolised by xanthine oxidase to inactive 6-thiouric acid which is excreted in the urine; inorganic sulfate may also be present.
- Half life0.90 h
- ExcretionAbout 50% of an oral dose is excreted in the urine in 24 h, up to 8% as unchanged drug. Small amounts are excreted for up to 17 days. Mercaptopurine is a metabolite of azathioprine.
- Urinary Excretion22
- Clerance11 ml/min/kg
- ToxicitySigns and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis.
- LD50 (rat)LD50=425 mg/kg
- LD50 (mouse)LD50=480 mg/kg