• Molecular NamePhentermine
  • Synonym(alpha,alpha)-Dimethylphenethylamine; Phentermine Hcl; Phentermine Hydrochloride
  • Weight149.237
  • Drugbank_IDDB00191
  • ACS_NO122-09-8
  • Show 3D model
  • LogP (experiment)1.9
  • LogP (predicted, AB/LogP v2.0)2.14
  • pka10.1
  • LogD (pH=7, predicted)-0.55
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)0.83
  • LogSw (predicted, AB/LogsW2.0)0.2
  • Sw (mg/ml) (predicted, ACD/Labs)3.3
  • No.of HBond Donors2
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds2
  • TPSA26.02
  • StatusFDA approved
  • AdministrationOral, Insufflation, Intravenous
  • PharmacologyAn appetite suppressant of the amphetamine and phenethylamine class.
  • Absorption_valueN/A
  • Absorption (description)Phentermine is rapidly absorbed after oral ingestion.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding96.3
  • Volume of distribution (VD)3 to 4 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life19~24 h
  • ExcretionUrinary elimination
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A