- Molecular NamePhentermine
- Synonym(alpha,alpha)-Dimethylphenethylamine; Phentermine Hcl; Phentermine Hydrochloride
- Weight149.237
- Drugbank_IDDB00191
- ACS_NO122-09-8
- Show 3D model
- LogP (experiment)1.9
- LogP (predicted, AB/LogP v2.0)2.14
- pka10.1
- LogD (pH=7, predicted)-0.55
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)0.83
- LogSw (predicted, AB/LogsW2.0)0.2
- Sw (mg/ml) (predicted, ACD/Labs)3.3
- No.of HBond Donors2
- No.of HBond Acceptors1
- No.of Rotatable Bonds2
- TPSA26.02
- StatusFDA approved
- AdministrationOral, Insufflation, Intravenous
- PharmacologyAn appetite suppressant of the amphetamine and phenethylamine class.
- Absorption_valueN/A
- Absorption (description)Phentermine is rapidly absorbed after oral ingestion.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding96.3
- Volume of distribution (VD)3 to 4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life19~24 h
- ExcretionUrinary elimination
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
- LD50 (rat)N/A
- LD50 (mouse)N/A