• Molecular NameMethamphetamine
  • Synonym(+ )-methylamphetamine; (+)-(s)-deoxyephedrine; (+)-(s)-n-alpha-dimethylphenethylamine; (+)-2-(N-Methylamino)-1-phenylpropane; (+)-methamphetamine; (+)-methylamphetamine; (+)-n-methylamphetamine; (+)-n,alpha-dimethyl-beta-phenylethylamine; (+)-n,alpha-dimethylphenethylamine; (2S)-N-methyl-1-phenylpropan-2-amine; (s)-(+)-deoxyephedrine; (s)-(+)-methamphetamine; (s)-(+)-n,alpha,dimethylphenethylamine; (s)-methamphetamine; (s)-methylamphetamine; (s)-n,alpha-dimethylbenzeneethanamine; (s)-n,alpha-dimethylbenzeneethanoamine; 1-Phenyl-2-methylamino-propan [German]; 1-Phenyl-2-methylaminopropane; 2S-(+)-Methamphetamine; D-(s)-methamphetamine; d-1-Phenyl-2-methylaminopropan [German]; D-1-Phenyl-2-methylaminopropane; D-deoxyephedrine; D-desoxyephedrine; D-methamphetamine; D-methylamphetamine; D-n-methylamphetamine; D-n,alpha-dimethylphenethylamine; D-phenylisopropylmethylamine; Desoxyephedrine hydrochloride; Ice; L-methamphetamine; Metamfetamina [inn-spanish]; Metamfetaminum [inn-latin]; Metamphetamine; Metanfetamina [inn-spanish]; Meth; Methamphetaminum [inn-latin]; Methyl-beta-phenylisopropylamine; Methylamphetamine; N-Methyl-1-phenyl-2-propanamine; N-methyl-beta-phenylisopropylamin [german]; N-methyl-beta-phenylisopropylamine; N-methylamphetamine; S-(+)-methamphetamine
  • Weight149.237
  • Drugbank_IDDB01577
  • ACS_NO537-46-2
  • Show 3D model
  • LogP (experiment)2.07
  • LogP (predicted, AB/LogP v2.0)2.25
  • pkaN/A
  • LogD (pH=7, predicted)-0.64
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.83
  • LogSw (predicted, AB/LogsW2.0)5.0
  • Sw (mg/ml) (predicted, ACD/Labs)6.58
  • No.of HBond Donors1
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds3
  • TPSA12.03
  • StatusFDA approved
  • AdministrationOral Recreational: Oral, I.V., I.M., Insufflation, Inhalation, Rectal
  • PharmacologyA psychostimulant and sympathomimetic drug.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability67.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMain metabolites of methamphetamine are amphetamine[1], 4-hydroxymethamphetamine, 4-hydroxyamphetamine and some of the methamphetamine remains unchanged until excretion.
  • Half life9~15 h
  • ExcretionIt is excreted by the kidneys, and its half-life depends on urinary pH.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A