- Molecular NameEthchlorvynol
- SynonymAethyl-chlorvynol; Etchlorvinolo; Ethchlorovynol; Ethchlorvinol; Ethchlorvinyl; Ethclorvynol; Ethochlorvynol; Ethychlorvynol
- Weight144.601
- Drugbank_IDDB00189
- ACS_NO113-18-8
- Show 3D model
- LogP (experiment)1.74
- LogP (predicted, AB/LogP v2.0)1.7
- pkaN/A
- LogD (pH=7, predicted)1.7
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.66
- LogSw (predicted, AB/LogsW2.0)4.62
- Sw (mg/ml) (predicted, ACD/Labs)3.15
- No.of HBond Donors1
- No.of HBond Acceptors1
- No.of Rotatable Bonds3
- TPSA20.23
- StatusFDA approved, US withdrawn
- AdministrationN/A
- PharmacologyA sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding42.5
- Volume of distribution (VD)2~3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, about 1.1.
- MetabollsmIt is extensively metabolised; the major metabolite found in the blood and urine of poisoned patients is 1-chloro-3-ethynylpent-1-ene-3,4-diol; other metabolites include 1-chloro-3-ethynylpent-1-ene-3,5-diol and 1-chloro-3-ethylpent-1-ene-3,4-diol. Ethchlorvynol is highly localised in the tissues, particularly in adipose tissue, and is released very slowly.
- Half lifeDistribution half-life, about 1 to 3 h and elimination half-life of 10 to 20 h, increased in overdose cases.
- ExcretionLess than 0.1% of a dose is excreted in the urine in 24 h as unchanged drug or its glucuronide conjugate. Ethchlorvynol crosses the placenta.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose is 15 g, although death has occurred after the acute ingestion of 2.5 g. Plasma concentrations greater than about 20 mg/L are associated with toxic effects. Prolonged use of ethchlorvynol may lead to dependence of the barbiturate–alcohol type.
- LD50 (rat)N/A
- LD50 (mouse)N/A