- Molecular NameValproic_acid
- SynonymDi-n-propylacetic acid; Di-n-propylessigsaure; Dipropylacetic acid; DPA; Kyselina 2-propylvalerova; Myproic Acid; n-Dipropylacetic acid; n-DPA; Propylvaleric acid; Sodium hydrogen divalproate; Valproate semisodique [French]; Valproate semisodium; Valproato semisodico [Spanish]; Valproatum seminatricum [Latin]
- Weight144.214
- Drugbank_IDDB00313
- ACS_NO99-66-1
- Show 2D model
- LogP (experiment)2.8
- LogP (predicted, AB/LogP v2.0)2.66
- pka4.6
- LogD (pH=7, predicted)0.56
- Solubility (experiment)Slightly soluble
- LogS (predicted, ACD/Labs)(ph=7)0.32
- LogSw (predicted, AB/LogsW2.0)3.34
- Sw (mg/ml) (predicted, ACD/Labs)2.09
- No.of HBond Donors1
- No.of HBond Acceptors2
- No.of Rotatable Bonds5
- TPSA37.3
- StatusFDA approved
- AdministrationOral, intravenous
- PharmacologyA chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and less commonly major depression. It is also used to treat migraine headaches and schizophrenia.
- Absorption_value98.0
- Absorption (description)Rapid absorption from gastrointestinal tract.
- Caco_2N/A
- Bioavailability100.0
- Protein binding93.0
- Volume of distribution (VD)0.22 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmValproic Acid is metabolized almost entirely by the liver. In adult patients on monotherapy, 30-50% of an administered dose appears in urine as a glucuronide conjugate. Mitochondrial beta-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose. Usually, less than 15-20% of the dose is eliminated by other oxidative mechanisms. Less than 3% of an administered dose is excreted unchanged in urine.
- Half life14 h
- ExcretionLess than 3% excreted unchanged in urine.
- Urinary Excretion1.8
- Clerance0.11 ml/min/kg
- ToxicityOral, mouse: LD50 = 1098 mg/kg; Oral, rat: LD50 = 670 mg/kg. Symptoms of overdose may include coma, extreme drowsiness, and heart problems.
- LD50 (rat)N/A
- LD50 (mouse)N/A