• Molecular NameTrimethadione
  • SynonymTrimetadione; Trimethadion; Trimethdione
  • Weight143.142
  • Drugbank_IDDB00347
  • ACS_NO127-48-0
  • Show 3D model
  • LogP (experiment)-0.37
  • LogP (predicted, AB/LogP v2.0)-0.06
  • pkaN/A
  • LogD (pH=7, predicted)-0.06
  • Solubility (experiment)76.9 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.47
  • LogSw (predicted, AB/LogsW2.0)69.15
  • Sw (mg/ml) (predicted, ACD/Labs)48.13
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds0
  • TPSA46.61
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn oxazolidinedione anticonvulsant. It is used to treat epileptic conditions that are resistant to other treatments
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding90.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifetrimethadione about 16 h; dimethadione, half-life derived from urinary excretion data, 6 to 13 days.
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A