- Molecular NameTrimethadione
- SynonymTrimetadione; Trimethadion; Trimethdione
- Weight143.142
- Drugbank_IDDB00347
- ACS_NO127-48-0
- Show 3D model
- LogP (experiment)-0.37
- LogP (predicted, AB/LogP v2.0)-0.06
- pkaN/A
- LogD (pH=7, predicted)-0.06
- Solubility (experiment)76.9 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.47
- LogSw (predicted, AB/LogsW2.0)69.15
- Sw (mg/ml) (predicted, ACD/Labs)48.13
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds0
- TPSA46.61
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn oxazolidinedione anticonvulsant. It is used to treat epileptic conditions that are resistant to other treatments
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding90.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifetrimethadione about 16 h; dimethadione, half-life derived from urinary excretion data, 6 to 13 days.
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
- LD50 (rat)N/A
- LD50 (mouse)N/A