• Molecular NameSalicylic_acid
  • Synonym2-Carboxyphenol; 2-Hydroxybenzenecarboxylic acid; 2-Hydroxybenzoic acid; Acido salicilico; O-carboxyphenol; O-hydroxybenzoic acid; Orthohydroxybenzoic acid; Phenol-2-carboxylic acid; SA; Salicylate; Salicylic acid
  • Weight138.122
  • Drugbank_IDDB00936
  • ACS_NO69-72-7
  • Show 3D model
  • LogP (experiment)2.326
  • LogP (predicted, AB/LogP v2.0)2.43
  • pka3.0, 13.4 (25°)
  • LogD (pH=7, predicted)-1.32
  • Solubility (experiment)2.09 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.86
  • LogSw (predicted, AB/LogsW2.0)2.51
  • Sw (mg/ml) (predicted, ACD/Labs)8.53
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds1
  • TPSA57.53
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologySalicylic acid is known for its ability to ease aches and pains and reduce fevers. These medicinal properties, particularly fever relief, have been known since ancient times, and it was used as an anti-inflammatory drug.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2-4.79
  • Bioavailability995.0
  • Protein binding70.0
  • Volume of distribution (VD)0.14~0.2 L/kg (dose-dependent)
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifedose-dependent (2~4 h after salicylate doses of less than 3 g, increasing to about 19 h after large doses).
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityOral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A