- Molecular NameAllopurinol
- SynonymAllopurinol Sodium; Allopurinolum [INN-Latin]; Alopurinol [INN-Spanish]
- Weight136.114
- Drugbank_IDDB00437
- ACS_NO315-30-0
- Show 3D model
- LogP (experiment)-0.55
- LogP (predicted, AB/LogP v2.0)-0.73
- pka9.4
- LogD (pH=7, predicted)-0.74
- Solubility (experiment)0.748 mg/L
- LogS (predicted, ACD/Labs)(ph=7)-2.97
- LogSw (predicted, AB/LogsW2.0)7.73
- Sw (mg/ml) (predicted, ACD/Labs)0.14
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds0
- TPSA70.14
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout.
- Absorption_value80.0
- Absorption (description)Allopurinol is rapidly absorbed after oral administration.
- Caco_2N/A
- Bioavailability53.0
- Protein binding0.0
- Volume of distribution (VD)0.87 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic (80% oxypurinol, 10% allopurinol ribosides). The major metabolite, oxipurinol (alloxanthine), is active but less potent than allopurinol. Subjects with a genetic deficiency of xanthine oxidase are unable to metabolise allopurinol to oxipurinol.
- Half life1.2 h
- ExcretionThe excretion of unchanged drug appears to vary with acute or chronic administration, less than 10% of a single dose being excreted unchanged in the urine whereas about 30% is excreted in the urine as unchanged drug after chronic administration. Most of the remainder of a dose is slowly excreted in the urine as oxipurinol; about 20% of a dose is eliminated in the faeces in 72 h.
- Urinary Excretion12
- Clerance9.9 mL/min/kg.
- ToxicityLD50=214 mg/kg (in mice)
- LD50 (rat)N/A
- LD50 (mouse)N/A