- Molecular NameAmphetamine
- Synonym(+/-)-Benzedrine; (+/-)-beta-Phenylisopropylamine; (+/-)-Desoxynorephedrine; [1-(3-Methoxyphenyl)-2-propyl]amine; 1-Methyl-2-phenylethylamine; 1-Phenyl-2-aminopropane; 3-Methoxy-a-methylbenzeneethanamine; 3-Methoxyamphetamine; 3-Methoxyphenylisopropylamine; alpha-Methylbenzeneethaneamine; Amfetamine; Amphetamine Sulfate; beta-Aminopropylbenzene; beta-phenyl-isopropylamine; dl-1-Phenyl-2-aminopropane; DL-alpha-Methylphenethylamine; dl-Amphetamine; dl-Benzedrine; Fenylo-izopropylaminyl; m-Methoxy-a-methylphenethylamine; m-Methoxyamphetamine; Methamphetamine HCL; Phenylisopropylamine
- Weight135.21
- Drugbank_IDDB00182
- ACS_NO300-62-9
- Show 3D model
- LogP (experiment)1.8
- LogP (predicted, AB/LogP v2.0)1.82
- pka10.1
- LogD (pH=7, predicted)-0.87
- Solubility (experiment)Slightly
- LogS (predicted, ACD/Labs)(ph=7)0.87
- LogSw (predicted, AB/LogsW2.0)1.86
- Sw (mg/ml) (predicted, ACD/Labs)5.42
- No.of HBond Donors2
- No.of HBond Acceptors1
- No.of Rotatable Bonds2
- TPSA26.02
- StatusFDA approved
- AdministrationOral, Intravenous, Vaporization, Insufflation, Rectal, Sublingual
- PharmacologyA psychostimulant drug that is known to produce increased wakefulness and focus in association with decreased fatigue and appetite. Amphetamine is related to drugs such as methamphetamine and dextroamphetamine, which are a group of potent drugs that act by increasing levels of dopamine and norepinephrine in the brain, inducing euphoria.
- Absorption_value90.0
- Absorption (description)Amphetamine has been shown to both diffuse through the cell membrane and travel via the dopamine transporter (DAT) to increase concentrations of dopamine in the neuronal terminal.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding27.5
- Volume of distribution (VD)3 to 4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic (CYP2D6)
- Half life4~8 h when the urine is acidic and about 12 h in subjects whose urinary pH values are uncontrolled
- ExcretionRenal; significant portion unaltered
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLD50=180 mg/kg(s.c in rat). The most common presenting symptoms seen are agitation, hallucinations, suicidal behaviour, and chest pain.
- LD50 (rat)N/A
- LD50 (mouse)N/A