- Molecular NameAdenine
- Synonym1H-Purin-6-amine; 6-Aminopurine; Adenin; Adeninimine; Vitamin B4
- Weight135.13
- Drugbank_IDDB00173
- ACS_NO73-24-5
- Show 3D model
- LogP (experiment)-0.05
- LogP (predicted, AB/LogP v2.0)0.39
- pkaN/A
- LogD (pH=7, predicted)0.38
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.62
- LogSw (predicted, AB/LogsW2.0)0.62
- Sw (mg/ml) (predicted, ACD/Labs)3.2
- No.of HBond Donors3
- No.of HBond Acceptors5
- No.of Rotatable Bonds0
- TPSA80.48
- StatusFDA approved
- AdministrationN/A
- PharmacologyAdenine (sometimes known as vitamin B4) combines with the sugar ribose to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding AMP, ADP and ATP . These adenine derivatives perform important functions in cellular metabolism. Adenine is one of four nitrogenous bases utilized in the synthesis of nucleic acids. A modified form of adenosine monophosphate (cyclic AMP) is an imporant secondary messenger in the propagation of many hormonal stimuli. Adenine is an integral part of the structure of many coenzymes. Adenosine (adenine with a ribose group) causes transient heart block in the AV node of the heart. In individuals suspected of suffering from a supraventricular tachycardia (SVT), adenosine is used to help identify the rhythm. Certain SVTs can be successfully terminated with adenosine.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A