Dipeptidyl peptidase 1
Target information
- CovInDB Protein
- P53634
- Name
- Dipeptidyl peptidase 1
- Encoding Gene
- CTSC
- Synonyms
-
- Cathepsin C
- Cathepsin J
- Dipeptidyl peptidase I
- DPP-I
- DPPI
- Dipeptidyl transferase
- Dipeptidyl peptidase I exclusion domain chain
- Dipeptidyl peptidase I heavy chain
- Dipeptidyl peptidase I light chain
- Taxonomy
- Homo sapiens (Human)
- Description
-
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
- Sequence
-
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
- Active Site
-
Feature Key Position(s) Description Active site 258 None Binding site 302 Chloride Binding site 304 Chloride; via amide nitrogen Binding site 347 Chloride Active site 405 None Active site 427 None - Structure
-
Check covalent ligand-protein complexes.
PDB: 6IC6
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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