tRNA (cytosine(38)-C(5))-methyltransferase
Target information
- CovInDB Protein
- O14717
- Name
- tRNA (cytosine(38)-C(5))-methyltransferase
- Encoding Gene
- TRDMT1
- Synonyms
-
- DNA (cytosine-5)-methyltransferase-like protein 2
- DNA methyltransferase homolog HsaIIP (DNA MTase homolog HsaIIP; M.HsaIIP)
- PuMet
- Taxonomy
- Homo sapiens (Human)
- Description
-
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344).
Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495). - Sequence
-
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
- Active Site
-
Feature Key Position(s) Description None None None - Structure
- Not Available
- Reference
- UniProt
Covalent Inhibitors
| Structure | Rank | ID | Warhead | Reaction Mechanism | Target Site | Activity Type | Relation | Value | Unit | Experiment Method | Assay | Reference |
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